|
Symbol Name ID |
Cd247
CD247 antigen MGI:88334 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Decreased circulating IgG2 level |
Increased circulating IgG level |
Increased circulating IgM level |
Complete or near-complete absence of specific antibody response to tetanus vaccine |
Autoimmune hemolytic anemia |
Eosinophilia |
T lymphocytopenia |
Erythroderma |
Recurrent pneumonia |
Anti-smooth muscle antibody positivity |
Antimitochondrial antibody positivity |
Immunodeficiency |
Recurrent candida infections |
Recurrent herpes |
| Disease(s) Associated with CD247 | ||||||||||||||||
| immunodeficiency 25 |
| Mouse Phenotypes | immune system phenotype |
decreased thymocyte apoptosis |
abnormal T cell proliferation |
decreased T cell proliferation |
decreased splenocyte proliferation |
enlarged thymus cortex |
small thymus medulla |
small thymus |
thymus hypoplasia |
decreased thymocyte number |
abnormal thymocyte activation |
enlarged spleen |
abnormal T cell differentiation |
abnormal T-helper 1 cell differentiation |
abnormal double-negative T cell morphology |
increased double-negative T cell number |
decreased double-positive T cell number |
abnormal gamma-delta T cell differentiation |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased NK T cell number |
absent gamma-delta intraepithelial T cell |
increased regulatory T cell number |
decreased single-positive T cell number |
abnormal NK cell morphology |
abnormal T cell morphology |
abnormal T-helper 1 cell morphology |
abnormal NK T cell morphology |
abnormal alpha-beta intraepithelial T cell morphology |
abnormal single-positive T cell number |
abnormal intraepithelial T cell morphology |
abnormal NK cell physiology |
increased natural killer cell mediated cytotoxicity |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 1 physiology |
abnormal regulatory T cell physiology |
enlarged lymph nodes |
increased interferon-gamma secretion |
increased susceptibility to experimental autoimmune encephalomyelitis |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||
| Cd247m1Btlr/Cd247m1Btlr | |||||||||||||||||||||||||||||||||||||||||
| Cd247tm1Lov/Cd247tm1Lov | |||||||||||||||||||||||||||||||||||||||||
| Cd247tm1Mal/Cd247tm1Mal | |||||||||||||||||||||||||||||||||||||||||
| Cd247tm1Mhu/Cd247tm1Mhu | * | ||||||||||||||||||||||||||||||||||||||||
| Cd247tm1Tks/Cd247tm1Tks | |||||||||||||||||||||||||||||||||||||||||
| Cd247tm2.1Lov/Cd247tm2.1Lov | * | ||||||||||||||||||||||||||||||||||||||||
| Cd247tm1Lov/Cd247tm2.1Lov | * | ||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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